Description

Boronic Acid, B-(2-Chloro-4,6-Difluorophenyl)- is a high-purity, halogenated arylboronic acid derivative, a critical building block in modern synthetic chemistry. Its primary value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for developing active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs) via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific halogenated biaryl motifs.
• Material Science Research: Serves as a monomer or building block for creating novel organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Medicinal Chemistry: Employed in the discovery and optimization of new chemical probes and drug candidates, especially in fragment-based drug design.
• Catalyst Ligand Synthesis: Can be utilized to synthesize sophisticated ligands for asymmetric catalysis and other transition metal-catalyzed processes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring specific halogenated boronic acids.

Basic Information

Item	Detail
Product Name	Boronic Acid, B-(2-Chloro-4,6-Difluorophenyl)-
CAS No.	1373393-48-6
Molecular Formula	C6H4BClF2O2
Molecular Weight	191.36 g/mol
Synonyms	(2-Chloro-4,6-difluorophenyl)boronic acid; 2-Chloro-4,6-difluorobenzeneboronic acid; B-(2-Chloro-4,6-difluorophenyl)boronic acid; 2-Chloro-4,6-difluorophenylboronic acid; (2-Chloro-4,6-difluorophenyl)boronic acid, 95%; Boronic acid, B-(2-chloro-4,6-difluorophenyl)-; 1373393-48-6
EINECS	Contact for details

Quality Control

Every batch of Boronic Acid, B-(2-Chloro-4,6-Difluorophenyl)- is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high standards required for research and commercial synthesis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality commitment supports applications in GMP and ISO-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.