Description

(1-tert-Butoxycarbonylpyrrolo[2,3-C]Pyridin-2-Yl)Boronic Acid CAS NO 1373273-48-3 is a high-purity, advanced pharmaceutical intermediate belonging to the class of heterocyclic boronic acids. This compound is a critical building block in modern medicinal chemistry, enabling the precise construction of complex molecular architectures through cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug candidates.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic acid reagent for the palladium-catalyzed formation of carbon-carbon bonds, essential for creating complex heterocyclic scaffolds in drug discovery.
• Pharmaceutical Intermediate Synthesis: A vital precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of heterobifunctional molecules designed for targeted protein degradation, a cutting-edge therapeutic modality.
• Kinase Inhibitor Research: Integral to the synthesis of small molecule inhibitors targeting specific kinases involved in cancer cell proliferation and signaling.
• Chemical Biology & Probe Development: Employed in the creation of chemical probes to study biological processes and identify new drug targets.
• Process Chemistry & Scale-Up: Supports route scouting and optimization from milligram to kilogram scale for clinical trial material manufacturing.

Basic Information

Product Name	(1-tert-Butoxycarbonylpyrrolo[2,3-C]Pyridin-2-Yl)Boronic Acid
CAS No.	1373273-48-3
Molecular Formula	C₁₆H₂₁BN₂O₄
Molecular Weight	316.16 g/mol
Synonyms	1-Boc-7-azaindole-2-boronic acid; 1-(tert-Butoxycarbonyl)-1H-pyrrolo[2,3-c]pyridine-2-boronic acid; 1-Boc-1H-pyrrolo[2,3-c]pyridine-2-boronic acid; 1-N-Boc-7-azaindole-2-boronic acid; 2-Borono-1-(tert-butoxycarbonyl)-1H-pyrrolo[2,3-c]pyridine; 1H-Pyrrolo[2,3-c]pyridine-2-boronic acid, 1-[(1,1-dimethylethoxy)carbonyl]-; BOC-7-Azaindole-2-Boronic Acid; 1-Boc-7-Azaindol-2-ylboronic acid
EINECS	Contact for details

Quality Control

Our (1-tert-Butoxycarbonylpyrrolo[2,3-C]Pyridin-2-Yl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.