Description

Propanedioic Acid, 2-[2-Amino-4-(Trifluoromethyl)Phenyl]-, 1,3-Dimethyl Ester is a high-purity, specialized organic intermediate featuring a trifluoromethylphenyl core. This compound is valued for its role as a critical building block in the synthesis of advanced active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethyl group is a key structural motif for enhancing biological activity and metabolic stability. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for developing novel compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of APIs, particularly in therapeutic areas where the trifluoromethyl group is beneficial, such as in anti-inflammatory, antiviral, or anticancer agents.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl moiety.
• Fine Chemical Production: Used in custom synthesis and research-scale production of complex organic molecules for material science and specialty chemicals.
• Research & Development: Employed in academic and industrial R&D labs for method development, structure-activity relationship (SAR) studies, and exploring new chemical entities.
• Ligand and Catalyst Precursor: Potential use in the synthesis of specialized ligands for catalysis or metal-organic frameworks (MOFs).

Basic Information

Product Name	Propanedioic Acid, 2-[2-Amino-4-(Trifluoromethyl)Phenyl]-, 1,3-Dimethyl Ester
CAS No.	1373232-95-1
Molecular Formula	C₁₂H₁₂F₃NO₄
Molecular Weight	291.23 g/mol
Synonyms	Dimethyl 2-(2-Amino-4-(trifluoromethyl)phenyl)malonate; 2-(2-Amino-4-(trifluoromethyl)phenyl)malonic Acid Dimethyl Ester; 1,3-Dimethyl 2-[2-Amino-4-(trifluoromethyl)phenyl]propanedioate; 2-Amino-4-(trifluoromethyl)phenylmalonic Acid Dimethyl Ester; Malonic acid, [2-amino-4-(trifluoromethyl)phenyl]-, dimethyl ester; CAS 1373232-95-1
EINECS	Contact for details

Quality Control

Our Propanedioic Acid, 2-[2-Amino-4-(Trifluoromethyl)Phenyl]-, 1,3-Dimethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.