Description

1-(4-Chlorophenyl)-2-(3,4-Difluorophenyl)Ethanone is a high-purity, fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its unique structure, featuring both chloro and difluoro substituents, makes it a valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research institutions and pharmaceutical development teams working on novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in kinase inhibitor and CNS-active compound libraries.
• Agrochemical Synthesis: Serves as a precursor in the design of next-generation herbicides and fungicides, leveraging the bioactivity of the difluorophenyl moiety.
• Liquid Crystal & OLED Material Research: Used in the synthesis of fluorinated aromatic cores for electronic and photonic materials due to its ability to modify polarity and conjugation.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Chemical Biology Probes: Employed in the development of fluorescent tags and molecular probes where specific halogenated aromatic groups are required.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, particularly in halogenation and fluorination chemistry.

Basic Information

Product Name	1-(4-Chlorophenyl)-2-(3,4-Difluorophenyl)Ethanone
CAS No.	1373156-53-6
Molecular Formula	C14H9ClF2O
Molecular Weight	266.67 g/mol
Synonyms	2-(3,4-Difluorophenyl)-1-(4-chlorophenyl)ethanone; 4'-Chloro-3',4'-difluorochalcone; 1-(4-Chlorophenyl)-2-(3,4-difluorophenyl)ethan-1-one; (4-Chlorophenyl)(3,4-difluorophenyl)methanone (tautomeric form); p-Chloro-3,4-difluorochalcone; 3,4-Difluoro-4'-chlorochalcone; 1373156-53-6; Ketone, (4-chlorophenyl)(3,4-difluorophenyl)-
EINECS	Contact for details

Quality Control

Our 1-(4-Chlorophenyl)-2-(3,4-Difluorophenyl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical data is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.