Description

2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline is a high-value, synthetically versatile boronic ester derivative of aniline, serving as a critical building block in modern organic synthesis. Its primary value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and specialty chemical development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing biphenyl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific halogenated aryl structures.
• Material Science: Serves as a monomer or functionalization agent in the creation of organic electronic materials, such as polymers for OLEDs or conductive films.
• Ligand & Catalyst Development: Employed to create novel bidentate or polydentate ligands for transition metal catalysis.
• Chemical Biology & Proteomics: Utilized as a building block for synthesizing molecular probes, tags, or inhibitors that target specific biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses producing bespoke organic compounds for client R&D programs.

Basic Information

Product Name	2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
CAS No.	1371630-51-1
Molecular Formula	C12H16BCl2NO2
Molecular Weight	288.0 g/mol
Synonyms	(4-Amino-3,5-dichlorophenyl)boronic acid pinacol ester; 2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-dichloroaniline; 2,6-Dichloro-4-(pinacolatoboryl)aniline; 3,5-Dichloro-4-(pinacolatoboryl)aniline; 1371630-51-1; Boronic acid, B-(4-amino-3,5-dichlorophenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Every batch of 2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling reactions and advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot and provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0% (Area Percent)
Purity (NMR)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.