Description

4,4'-(6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine-2,4-Diyl)Dimorpholine is a high-purity, advanced pharmaceutical intermediate featuring a pyrimidine core functionalized with both morpholine and a pinacol boronate ester group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl and heterobiaryl scaffolds. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for oncology, antiviral, and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those containing complex heterocyclic architectures.
• Suzuki-Miyaura Cross-Coupling Reagent: The boronate ester moiety serves as a versatile handle for palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides.
• Medicinal Chemistry Research: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to optimize drug-like properties.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds or molecular probes for target identification and validation.
• Agrochemical Intermediate: Potential use in the development of new herbicides or fungicides containing functionalized pyrimidine structures.
• Material Science Precursor: Can be utilized in the synthesis of organic electronic materials or metal-organic frameworks (MOFs) with specific ligand properties.

Basic Information

Item	Details
Product Name	4,4'-(6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine-2,4-Diyl)Dimorpholine
CAS No.	1370351-45-3
Molecular Formula	C18H27BN4O4
Molecular Weight	374.25 g/mol
Synonyms	2,4-Dimorpholino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,4-dimorpholinopyrimidine; 4,4'-(6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2,4-diyl)dimorpholine; 2,4-Bis(morpholin-4-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; Boronic acid, B-[2,4-bis(4-morpholinyl)-6-pyrimidinyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our 4,4'-(6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine-2,4-Diyl)Dimorpholine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.