Description

Benzene, 2-Chloro-4-(1,1-Dimethylethyl)-1-Iodo- is a high-value, halogenated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines chlorine, iodine, and a tert-butyl group on a benzene ring, offering multiple reactive sites for selective functionalization and cross-coupling reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, such as active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly in constructing complex aromatic cores for oncology and CNS-targeted therapies.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the halogenated structure contributes to biological activity.
• Material Science Research: Acts as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings for carbon-carbon bond formation.
• Ligand and Catalyst Development: Utilized to synthesize novel phosphine or N-heterocyclic carbene (NHC) ligands for asymmetric catalysis.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in chemical manufacturing.

Basic Information

Product Name	Benzene, 2-Chloro-4-(1,1-Dimethylethyl)-1-Iodo-
CAS No.	1369952-10-2
Molecular Formula	C10H12ClI
Molecular Weight	294.56 g/mol
Synonyms	2-Chloro-4-tert-butyl-1-iodobenzene; 1-Chloro-3-tert-butyl-4-iodobenzene; 4-tert-Butyl-2-chloro-1-iodobenzene; 2-Chloro-1-iodo-4-tert-butylbenzene; 1-Iodo-2-chloro-4-tert-butylbenzene; 4-(tert-Butyl)-2-chloroiodobenzene; 2-Chloro-4-(tert-butyl)iodobenzene; 4-tert-Butyl-2-chloroiodobenzene
EINECS	Contact for details

Quality Control

Our Benzene, 2-Chloro-4-(1,1-Dimethylethyl)-1-Iodo- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency essential for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.