Description

3-Chloro-6-Fluorophenyl Cyclopropyl Ketone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular scaffold, which combines halogenated aromatic and strained cyclopropyl functionalities, enabling the construction of complex molecules with tailored properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorinated phenyl moiety.
• Material Science: Serves as a building block for advanced polymers and liquid crystals, where the ketone and cyclopropyl groups can influence material stability and optical properties.
• Organic Synthesis: Employed in cross-coupling reactions, carbonyl chemistry, and ring-opening transformations to create diverse chemical libraries for screening.
• Chemical Biology: Utilized as a molecular probe or tag in studying enzyme mechanisms and protein interactions due to its distinct structural features.

Basic Information

Product Name	3-Chloro-6-Fluorophenyl Cyclopropyl Ketone
CAS No.	1368550-33-7
Molecular Formula	C10H8ClFO
Molecular Weight	198.62 g/mol
Synonyms	Cyclopropyl(3-chloro-6-fluorophenyl)methanone; 1-(3-Chloro-6-fluorophenyl)-1-cyclopropylmethanone; 3-Chloro-6-fluorobenzoylcyclopropane; (3-Chloro-6-fluorophenyl)(cyclopropyl)ketone; 3-Chloro-α-fluoro-α-cyclopropylacetophenone (incorrect but common search variant); Ketone, 3-chloro-6-fluorophenyl cyclopropyl; CAS 1368550-33-7
EINECS	Contact for details

Quality Control

Our 3-Chloro-6-Fluorophenyl Cyclopropyl Ketone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO 9001 guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.