Description

Methyl 1-Isopropyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrole-2-Carboxylate is a high-value, multi-functional boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in constructing heterocyclic cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific pyrrole-boronate motifs.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers.
• Suzuki-Miyaura Cross-Coupling: A pivotal reagent for forming carbon-carbon bonds between aryl or heteroaryl halides and the boronate ester group under palladium catalysis.
• Chemical Biology & Proteomics: Serves as a versatile handle for bioconjugation and the synthesis of molecular probes and inhibitors.
• Academic & Industrial R&D: A valuable tool for synthetic methodology development and exploring new chemical spaces in medicinal chemistry.

Basic Information

Product Name	Methyl 1-Isopropyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrole-2-Carboxylate
CAS No.	1367830-46-3
Molecular Formula	C15H24BNO4
Molecular Weight	293.17 g/mol
Synonyms	1H-Pyrrole-2-carboxylic acid, 1-(1-methylethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; Methyl 1-isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-2-carboxylate; 1-Isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-2-carboxylic acid methyl ester; 1367830-46-3; Pinacol boronate ester of methyl 1-isopropyl-4-borono-1H-pyrrole-2-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 1-Isopropyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrole-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards expected for GMP intermediates and high-purity research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.