Description

5-Chloro-6-Fluoropyridin-3-Ylboronic Acid is a high-value boronic acid derivative and a crucial building block in modern synthetic chemistry. Its primary importance lies in enabling the efficient construction of complex pyridine-containing molecules through cross-coupling reactions like the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and fine chemicals. Its specific halogen substitution pattern makes it a sought-after intermediate for creating novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific halogenated pyridine scaffolds.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, ligands for catalysis, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: Primarily employed in Suzuki-Miyaura cross-coupling to form biaryl and heterobiaryl bonds, a fundamental transformation in medicinal and process chemistry.
• Chemical Biology & Diagnostics: Utilized in the development of molecular probes, sensors, and labeling agents due to its reactive boronic acid functional group.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up campaigns.

Basic Information

Item	Detail
Product Name	5-Chloro-6-Fluoropyridin-3-Ylboronic Acid
CAS No.	1366482-32-7
Molecular Formula	C5H4BClFNO2
Molecular Weight	175.36 g/mol
Synonyms	(5-Chloro-6-fluoropyridin-3-yl)boronic acid; 5-Chloro-6-fluoro-3-pyridineboronic acid; 3-Borono-5-chloro-6-fluoropyridine; 5-Chloro-6-fluoropyridine-3-boronic acid; (5-Chloro-6-fluoro-3-pyridinyl)boronic acid; 1366482-32-7; 5-Chloro-6-fluoro-3-pyridylboronic acid
EINECS	Contact for details

Quality Control

Our 5-Chloro-6-Fluoropyridin-3-Ylboronic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical applications, and our quality commitment ensures reliable and reproducible performance in your critical reactions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Assay (NMR)	≥95.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.