Description

4-(3-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl)Morpholine is a high-purity, advanced pharmaceutical intermediate featuring a morpholine-substituted phenylboronic ester pinacol group. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing biaryl and heterobiaryl structures, essential in drug discovery.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of potential therapeutic agents, including kinase inhibitors and other small molecule drugs.
• Organic Synthesis & Medicinal Chemistry Research: Used in academic and industrial R&D labs for exploring new chemical entities and structure-activity relationships (SAR).
• Ligand and Catalyst Development: Can be utilized in the preparation of novel ligands or organometallic catalysts for asymmetric synthesis.
• Material Science Research: Potential building block for creating organic electronic materials or functional polymers.

Basic Information

Product Name	4-(3-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl)Morpholine
CAS No.	1366131-54-5
Molecular Formula	C17H26BNO3
Molecular Weight	303.21 g/mol
Synonyms	4-(3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)morpholine; 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methylphenyl)morpholine; 2-(4-Morpholino-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(3-Methyl-4-(pinacolboryl)phenyl)morpholine; Morpholine, 4-[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-
EINECS	Contact for details

Quality Control

Our 4-(3-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl)Morpholine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.