Description

3-Methyl-4-(Piperidin-1-Yl)Phenylboronic Acid Pinacol Ester is a sophisticated boronic ester derivative, a crucial protected intermediate in modern synthetic chemistry. Its primary value lies in enabling efficient and selective Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl scaffolds. This high-purity building block is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly in the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those containing complex biaryl motifs for targets in oncology, CNS disorders, and inflammation.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific aryl-aryl couplings.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Probe Development: Serves as a versatile handle for bioconjugation and the synthesis of molecular probes for diagnostic and research applications.
• Catalyst & Ligand Preparation: Acts as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A critical reagent for CROs and CDMOs offering bespoke chemical synthesis services to global clients.

Basic Information

Item	Details
Product Name	3-Methyl-4-(Piperidin-1-Yl)Phenylboronic Acid Pinacol Ester
CAS No.	1366131-49-8
Molecular Formula	C19H30BNO2
Molecular Weight	315.26 g/mol
Synonyms	[4-(1-Piperidinyl)-3-methylphenyl]boronic acid pinacol ester; 3-Methyl-4-piperidin-1-ylbenzeneboronic acid pinacol ester; Pinacol [3-Methyl-4-(piperidin-1-yl)phenyl]boronate; B-[4-(1-Piperidinyl)-3-methylphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Methyl-4-(1-piperidinyl)phenylboronic acid pinacol ester; CAS 1366131-49-8; Boronic acid, B-[4-(1-piperidinyl)-3-methylphenyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our 3-Methyl-4-(Piperidin-1-Yl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems support development from research to commercial scale.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis and maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (HPLC)	≥98.0% (Total area %)
Water Content (KF)	≤0.5% w/w
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.