Description

2,4-Difluoro-n-(2-Methoxy-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Benzenesulfonamide is a high-value, advanced pharmaceutical intermediate featuring a key boronic ester functional group. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is an essential building block for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on creating novel active ingredients for small molecule therapeutics.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: The pinacol boronate ester moiety enables efficient carbon-carbon bond formation with aryl halides, facilitating the construction of complex molecular architectures.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides that require specific fluorinated and sulfonamide motifs.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of advanced organic electronic materials and polymers.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and process development projects.
• Library Synthesis for Drug Discovery: Employed in high-throughput and combinatorial chemistry to generate diverse compound libraries for biological screening.

Basic Information

Product Name	2,4-Difluoro-n-(2-Methoxy-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Benzenesulfonamide
CAS No.	1366131-40-9
Molecular Formula	C20H25BF2N2O5S
Molecular Weight	454.30 g/mol
Synonyms	2,4-Difluoro-N-[2-methoxy-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]benzenesulfonamide; 5-(2,4-Difluorophenylsulfonamido)-2-methoxy-4-methylpyridine-3-boronic acid pinacol ester; 1366131-40-9; Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]-; 3-Pyridineboronic acid, 5-[[(2,4-difluorophenyl)sulfonyl]amino]-2-methoxy-4-methyl-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles to ensure consistency and reliability for your critical synthesis steps. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and cGMP environments, supporting your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.