Description

2-(2-Chlorobenzyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 1365565-86-1 is a high-purity organoboron reagent, specifically a pinacol boronic ester derivative, valued for its role as a versatile synthetic building block. Its primary commercial value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific chlorobenzyl-substituted structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Medicinal Chemistry: Employed in the development of molecular probes, enzyme inhibitors, and other bioactive compounds for target validation and screening.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form new carbon-carbon bonds with high efficiency and functional group tolerance.
• Fine Chemical Production: Acts as a specialized intermediate in the multi-step synthesis of complex fragrances, dyes, and performance chemicals.

Basic Information

Product Name	2-(2-Chlorobenzyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1365565-86-1
Molecular Formula	C13H18BClO2
Molecular Weight	252.54 g/mol
Synonyms	(2-Chlorobenzyl)boronic acid pinacol ester; 2-(2-Chlorobenzyl)-1,3,2-dioxaborolane, 4,4,5,5-tetramethyl-; Pinacol (2-chlorobenzyl)boronate; (2-Chlorobenzyl)BPin; 2-Chlorobenzylboronic acid pinacol ester; B-(2-Chlorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1,3,2-Dioxaborolane, 2-[(2-chlorophenyl)methyl]-4,4,5,5-tetramethyl-
EINECS	Contact for details

Quality Control

Our production of 2-(2-Chlorobenzyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.