Description

1-Bromo-2-(cyclopentyloxy)-4-(trifluoromethyl)benzene is a high-value, multi-functional aromatic building block designed for advanced chemical synthesis. This compound is engineered to provide a unique combination of a bromo substituent for cross-coupling reactions and a trifluoromethyl group for modulating lipophilicity and metabolic stability. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and agrochemical sectors, enabling the development of novel active ingredients. Its specific structure makes it particularly valuable for creating complex molecules where precise electronic and steric properties are required.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science: Serves as a precursor for advanced organic electronic materials, including liquid crystals and charge-transport molecules.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for Suzuki, Stille, and Buchwald-Hartwig amination reactions to form new carbon-carbon and carbon-heteroatom bonds.
• Fluorine Chemistry: The CF3 group is utilized to study structure-activity relationships (SAR) and to improve the pharmacokinetic properties of candidate molecules.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	1-Bromo-2-(cyclopentyloxy)-4-(trifluoromethyl)benzene
CAS No.	1365271-60-8
Molecular Formula	C12H12BrF3O
Molecular Weight	309.13 g/mol
Synonyms	2-Bromo-1-(cyclopentyloxy)-4-(trifluoromethyl)benzene; 1-Bromo-2-cyclopentyloxy-4-trifluoromethylbenzene; Benzene, 1-bromo-2-(cyclopentyloxy)-4-(trifluoromethyl)-; 4-Trifluoromethyl-2-bromo-1-cyclopentyloxybenzene; 2-Bromo-4-(trifluoromethyl)phenyl cyclopentyl ether
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-2-(cyclopentyloxy)-4-(trifluoromethyl)benzene is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.