Description

(4-Chloro-2-(Hydroxymethyl)Phenyl)Boronic Acid is a versatile and highly functionalized boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a reactive boronic acid group for Suzuki-Miyaura cross-coupling reactions with a hydroxymethyl handle for further derivatization. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules and advanced intermediates in drug discovery and development pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and complex bioactive molecules via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, enabling the introduction of specific aromatic chlorohydroxymethyl motifs.
• Material Science Research: Employed in the development of organic electronic materials, polymers, and metal-organic frameworks (MOFs) due to its ability to form stable boronate esters.
• Chemical Biology & Proteomics: Acts as a valuable handle for bioconjugation and the development of chemical probes, sensors, and affinity purification ligands.
• Ligand Synthesis: Serves as a starting material for creating novel bidentate or tridentate ligands used in catalysis and coordination chemistry.
• Custom Synthesis & Contract Manufacturing: A high-demand building block for custom synthesis services catering to R&D and pilot-scale production needs.

Basic Information

Product Name	(4-Chloro-2-(Hydroxymethyl)Phenyl)Boronic Acid
CAS No.	1365244-07-0
Molecular Formula	C7H8BClO3
Molecular Weight	186.40 g/mol
Synonyms	(4-Chloro-2-(hydroxymethyl)phenyl)boronic acid; 2-(Hydroxymethyl)-4-chlorobenzeneboronic acid; 4-Chloro-2-(hydroxymethyl)benzeneboronic acid; (4-Chloro-2-hydroxymethylphenyl)boronic acid; B-(4-Chloro-2-(hydroxymethyl)phenyl)boronic acid; 4-Chloro-2-(hydroxymethyl)phenylboronic acid; 1365244-07-0; 4-Chloro-2-hydroxymethylphenylboronic acid
EINECS	Contact for details

Quality Control

Our (4-Chloro-2-(Hydroxymethyl)Phenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for research and industrial synthesis. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality parameters. Our commitment to supply chain reliability and batch-to-batch consistency supports your project timelines and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.