Description

1-(Boc-Aminomethyl)-3-Fluorocyclobutane-Carboxylic Acid is a high-value, multifunctional building block designed for advanced organic synthesis. This compound is critical for researchers and process chemists developing novel active pharmaceutical ingredients (APIs) and other fine chemicals, where precise molecular architecture is required. Its primary utility lies in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for constructing complex molecules with cyclobutane and fluorinated motifs.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially for protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Peptide Mimetics & PROTACs: Used to incorporate rigid, fluorinated cyclobutane scaffolds into peptide backbones or as a linker component in Proteolysis Targeting Chimeras (PROTACs).
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with enhanced metabolic stability and bioavailability.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced materials where the fluorocyclobutane unit imparts unique physical properties.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Product Name	1-(Boc-Aminomethyl)-3-Fluorocyclobutane-Carboxylic Acid
CAS No.	1363380-71-5
Molecular Formula	C12H20FNO4
Molecular Weight	261.29 g/mol
Synonyms	3-Fluoro-1-[[(1,1-dimethylethoxy)carbonyl]aminomethyl]cyclobutanecarboxylic Acid; 1-[(tert-Butoxycarbonylamino)methyl]-3-fluorocyclobutanecarboxylic Acid; 1-((Boc-amino)methyl)-3-fluorocyclobutanecarboxylic Acid; 1-(Boc-aminomethyl)-3-fluorocyclobutanecarboxylic acid; N-Boc-1-amino-3-fluorocyclobutanemethane carboxylic acid; tert-Butyl (3-fluoro-1-(carboxymethyl)cyclobutyl)carbamate; 1363380-71-5
EINECS	Contact for details

Quality Control

Our production of 1-(Boc-Aminomethyl)-3-Fluorocyclobutane-Carboxylic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure consistency and reliability. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical specifications. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.