Description

2H-1,4-Benzoxazine, 3,4-Dihydro-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, heterocyclic boronic ester derivative that serves as a critical synthetic intermediate. Its primary value lies in enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds under mild conditions. This compound is essential for researchers and manufacturers in pharmaceutical development and advanced material science who require reliable, high-purity building blocks for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of new active ingredients for crop protection products.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as polymers for OLEDs or conductive films.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules for studying biological pathways and protein interactions.
• Ligand and Catalyst Development: Used to construct complex ligand frameworks for asymmetric catalysis and metal-organic frameworks (MOFs).
• Academic & Industrial R&D: A versatile reagent for method development and exploring new synthetic routes in organic chemistry laboratories.

Basic Information

Product Name	2H-1,4-Benzoxazine, 3,4-Dihydro-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1361110-64-6
Molecular Formula	C16H22BNO3
Molecular Weight	287.16 g/mol
Synonyms	7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-1,4-benzoxazine; 3,4-Dihydro-2H-1,4-benzoxazin-7-ylboronic acid pinacol ester; 7-(Pinacolatoboryl)-3,4-dihydro-2H-1,4-benzoxazine; 2H-1,4-Benzoxazine-7-boronic acid, 3,4-dihydro-, pinacol ester; 1361110-64-6; 7-Borono-3,4-dihydro-2H-1,4-benzoxazine pinacol ester
EINECS	Contact for details

Quality Control

Our production of 2H-1,4-Benzoxazine, 3,4-Dihydro-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for sensitive coupling reactions. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and GC to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) for long-term storage to maintain purity and reactivity. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.