Description

4-Trifluoromethyl-1-Phenylvinylboronic Acid Pinacol Ester is a high-value organoboron building block crucial for modern synthetic chemistry. Its core value lies in enabling the efficient construction of complex molecules containing the trifluoromethyl group, a key pharmacophore known to enhance metabolic stability and lipophilicity. This compound is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for advanced cross-coupling reactions, such as Suzuki-Miyaura couplings, to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Used in the development of advanced herbicides, fungicides, and insecticides where the CF3 group improves biological activity and environmental persistence.
• Material Science: Serves as a precursor for functionalized polymers and organic electronic materials, such as OLEDs and semiconductors, where the phenylvinylboronate moiety allows for precise structural tuning.
• Suzuki-Miyaura Cross-Coupling: Specifically employed as a versatile coupling partner with aryl or vinyl halides to introduce the 4-trifluoromethylstyryl moiety into complex molecular architectures.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for transition metal catalysis or as a scaffold for creating boron-based sensor molecules.

Basic Information

Product Name	4-Trifluoromethyl-1-Phenylvinylboronic Acid Pinacol Ester
CAS No.	1361046-91-4
Molecular Formula	C21H22BF3O2
Molecular Weight	374.21 g/mol
Synonyms	4-(Trifluoromethyl)styrylboronic acid pinacol ester; 2-(4-Trifluoromethylstyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-Methyl-3-[4-(trifluoromethyl)phenyl]allyl)boronic acid pinacol ester; 1-Phenyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)ethene; 4-Trifluoromethylstyrylboronic Acid Pinacol Ester; Vinylboronic Acid Pinacol Ester, 4-Trifluoromethyl-1-Phenyl-; B-[2-[4-(Trifluoromethyl)phenyl]ethenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethyl-1-Phenylvinylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducible performance in sensitive cross-coupling reactions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to maximize shelf-life stability. The compound is moisture-sensitive; keep the original container tightly sealed and desiccated.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.