Description

tert-Butyl 3-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Pyrrolidine-1-Carboxylate is a high-value, protected boronic ester derivative crucial for modern synthetic chemistry. This compound matters as a key advanced pharmaceutical intermediate (API) and a versatile building block for constructing complex molecular architectures via cross-coupling reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active compounds.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical, protected boronic acid ester reagent for forming carbon-carbon bonds in complex molecule synthesis.
• Pharmaceutical Intermediate: A key building block in the research and development of new active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the discovery and production of novel herbicides, fungicides, and insecticides requiring specific heterocyclic frameworks.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and conductive polymers, where precise molecular structure is essential.
• Medicinal Chemistry & Drug Discovery: Enables rapid parallel synthesis and library generation for high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Provides a stable, storable intermediate for optimizing and scaling manufacturing routes for commercial products.

Basic Information

Product Name	tert-Butyl 3-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Pyrrolidine-1-Carboxylate
CAS No.	1359974-18-7
Molecular Formula	C18H32BN3O4
Molecular Weight	365.28 g/mol
Synonyms	1-Boc-3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]pyrrolidine; tert-Butyl 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)pyrrolidine-1-carboxylate; 1-(1-Boc-3-Pyrrolidinyl)-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]pyrrolidine-1-carboxylic acid tert-butyl ester; BOC-Protected Pyrazole Boronic Ester; 1359974-18-7
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your GMP-compliant research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.