Description

8-(Trifluoromethyl)Isoquinolin-3-Amine is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique combination of the isoquinoline scaffold and the electron-withdrawing trifluoromethyl group, which is critical for modulating the physicochemical properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) targets, oncology, and anti-infective therapies.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the CF₃ group enhances bioavailability and metabolic stability.
• Material Science: Acts as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its aromatic and fluorinated character.
• Chemical Biology Probe: Employed in the design of molecular probes and inhibitors to study enzyme function and biological pathways.
• Catalyst Ligand Synthesis: Utilized for constructing sophisticated nitrogen-containing ligands used in asymmetric catalysis and transition metal complexes.
• Fluorine Chemistry Library: A valuable component for building diverse compound libraries focused on fluorine-containing motifs for high-throughput screening.

Basic Information

Item	Detail
Product Name	8-(Trifluoromethyl)Isoquinolin-3-Amine
CAS No.	1357945-83-5
Molecular Formula	C₁₀H₇F₃N₂
Molecular Weight	212.17 g/mol
Synonyms	3-Amino-8-(trifluoromethyl)isoquinoline; 8-(Trifluoromethyl)-3-isoquinolinamine; 8-Trifluoromethylisoquinolin-3-ylamine; 1357945-83-5; 8-CF3-Isoquinolin-3-amine; 3-Isoquinolinamine, 8-(trifluoromethyl)-; 8-Trifluoromethyl-3-aminoisoquinoline
EINECS	Contact for details

Quality Control

Every batch of 8-(Trifluoromethyl)Isoquinolin-3-Amine is produced and tested under strict quality management protocols to ensure consistency and purity for research and scale-up applications. Our standard quality commitment includes comprehensive analytical characterization using HPLC, GC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.