Description

n-(2-Chloro-6-Iodo-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Pivalamide is a highly functionalized pyridine derivative containing both halogen and boronic ester protecting groups. This compound is a critical advanced pharmaceutical intermediate (API) designed for use in cross-coupling reactions, most notably the Suzuki-Miyaura reaction. It is primarily required by pharmaceutical R&D and process chemistry teams for the efficient synthesis of complex, bioactive molecules, including potential drug candidates and agrochemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester precursor for constructing biaryl and heterobiaryl structures in medicinal chemistry.
• Pharmaceutical Intermediate: Used in the research and development of new active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Employed in the creation of novel herbicides, fungicides, and insecticides requiring complex pyridine-based scaffolds.
• Material Science Research: Acts as a building block for organic electronic materials, such as ligands for catalysts or components in organic light-emitting diodes (OLEDs).
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological systems and target engagement.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	n-(2-Chloro-6-Iodo-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Pivalamide
CAS No.	1357387-98-4
Molecular Formula	C16H23BClINO3
Molecular Weight	450.53 g/mol
Synonyms	Pivalamide, N-[2-chloro-6-iodo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]-; 2-Chloro-6-iodo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine, N-pivaloyl derivative; 3-(Pivalamido)-2-chloro-6-iodo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 1357387-98-4; Boronic ester pyridine intermediate; 2-Chloro-6-iodo-4-(pinacolatoboron)pyridin-3-yl pivalamide
EINECS	Contact for details

Quality Control

Our n-(2-Chloro-6-Iodo-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Pivalamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can compromise the reactivity of the boronic ester group. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.