Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)-1-(Triisopropylsilyl)-1H-Pyrrolo is a high-value, multi-functional organoboron building block designed for advanced synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and agrochemical development. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl and pyrrole motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the boronic ester functionality for efficient coupling.
• Material Science Research: Serves as a precursor for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where the pyrrole unit is valuable.
• Suzuki-Miyaura Cross-Coupling: The protected boronic ester group makes it a stable and reactive partner for palladium-catalyzed coupling with aryl/heteroaryl halides.
• Complex Molecule Construction: Facilitates the late-stage functionalization and diversification of complex molecules in medicinal chemistry and total synthesis projects.
• Chemical Biology Probes: Used to create labeled compounds or probes for studying biological processes and target engagement.

Basic Information

Item	Detail
Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)-1-(Triisopropylsilyl)-1H-Pyrrolo
CAS No.	1357387-66-6
Molecular Formula	C22H39BF3NO2Si
Molecular Weight	445.44 g/mol
Synonyms	5-(Trifluoromethyl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-4-boronic acid pinacol ester; 1-(Triisopropylsilyl)-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4-boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; TIPS-Protected Trifluoromethyl Pyrrolopyridine Boronic Ester
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)-1-(Triisopropylsilyl)-1H-Pyrrolo is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and process chemistry standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.