Description

5-Bromo-1-(Phenylsulfonyl)-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine CAS NO 1357387-25-7 is a high-value, multi-functional heterocyclic building block that combines a pyrrolopyridine core with both a sulfonyl protecting group and a boronic ester pinacol ester. This compound matters because it serves as a critical intermediate in modern synthetic chemistry, enabling the construction of complex molecules through versatile cross-coupling reactions. It is primarily needed by research scientists and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and advanced materials.

Application

This advanced boronic ester derivative is designed for precision synthesis in demanding research and development environments. Its primary applications include:

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester group enables efficient, palladium-catalyzed carbon-carbon bond formation with various aryl/heteroaryl halides.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with complex heterocyclic structures.
• Material Science: Serves as a precursor for creating organic electronic materials and functionalized polymers.
• Chemical Biology & Proteomics: Can be utilized for the synthesis of molecular probes and activity-based protein profiling reagents.
• Academic & Contract Research: An essential reagent for methodology development and exploring new synthetic pathways in organic chemistry.

Basic Information

Item	Details
Product Name	5-Bromo-1-(Phenylsulfonyl)-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1357387-25-7
Molecular Formula	C23H24BBrN2O4S
Molecular Weight	515.23 g/mol
Synonyms	5-Bromo-1-(phenylsulfonyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-(phenylsulfonyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 5-Bromo-1-(benzenesulfonyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; BRN 19115531
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-(Phenylsulfonyl)-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, meeting the stringent requirements of research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.