Description

n-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Pyridin-2-Yl)Pivalamide is a high-value, synthetically versatile boronic ester derivative, serving as a critical building block in modern organic synthesis. Its core value lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop novel active ingredients and functional molecules. The CAS number for this compound is 1357387-24-6.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology, leveraging the trifluoromethyl and pyridine motifs.
• Agrochemical Research: Used to create novel herbicides, fungicides, and insecticides, where the boronic ester group allows for efficient structure-activity relationship (SAR) studies and lead optimization.
• Material Science: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its ability to form conjugated systems.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of molecular probes and inhibitors for studying biological pathways.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form carbon-carbon bonds, a fundamental transformation in medicinal and process chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the custom synthesis of complex, patent-protected molecules.

Basic Information

Product Name	n-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Pyridin-2-Yl)Pivalamide
CAS No.	1357387-24-6
Molecular Formula	C17H24BF3N2O3
Molecular Weight	372.19 g/mol
Synonyms	Pivalamide, N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-2-pyridinyl]-; 2-Pivalamido-5-(trifluoromethyl)pyridine-3-boronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridin-2-amine, N-pivaloyl-; 1357387-24-6; 2-Pyridinecarboxamide, N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-2-pyridinyl]-2,2-dimethyl-
EINECS	Contact for details

Quality Control

Every batch of n-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Pyridin-2-Yl)Pivalamide is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for demanding research and scale-up applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature: 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.