Description

1,5-Dibromo-3-Fluoro-2-Methoxy-4-Methylbenzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty fine chemicals who require reliable access to high-quality, structurally precise intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its halogenated structure for bioactivity.
• Liquid Crystal Materials (LCs): Serves as a core building block for fluorine-containing liquid crystal compounds used in display technologies.
• Organic Electronic Materials: Employed in the development of organic semiconductors and charge-transport materials due to its electron-deficient aromatic system.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination to create biaryl and complex aromatic systems.
• Functional Material Research: Used in academic and industrial R&D for creating novel polymers, ligands, and metal-organic frameworks (MOFs).

Basic Information

Product Name	1,5-Dibromo-3-Fluoro-2-Methoxy-4-Methylbenzene
CAS No.	1357103-67-3
Molecular Formula	C8H7Br2FO
Molecular Weight	305.95 g/mol
Synonyms	1,5-Dibromo-3-fluoro-2-methoxy-4-methylbenzene; 2,6-Dibromo-4-fluoro-3-methoxytoluene; 4-Methyl-1,5-dibromo-3-fluoro-2-methoxybenzene; 3-Fluoro-2-methoxy-4-methyl-1,5-dibromobenzene; Benzene, 1,5-dibromo-3-fluoro-2-methoxy-4-methyl-; Halogenated Benzene Intermediate 1357103-67-3
EINECS	Contact for details

Quality Control

Our 1,5-Dibromo-3-Fluoro-2-Methoxy-4-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.