Description

2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethyl)Benzaldehyde is a high-value, multi-functional organic building block that combines a protected boronic ester with a reactive aldehyde group and a trifluoromethyl substituent. This compound matters for its critical role in modern synthetic chemistry, enabling the efficient construction of complex molecules through cross-coupling and subsequent functional group transformations. Pharmaceutical, agrochemical, and advanced materials researchers need it as a key intermediate for developing novel active ingredients and functional materials, particularly where the introduction of the trifluoromethyl group is desired for its beneficial effects on metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates containing trifluoromethylated biaryl motifs via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the CF3 group enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for studying biological processes, leveraging the unique properties of the boron and fluorine atoms.
• Cross-Coupling Reactions: The pinacol boronic ester group is a stable, versatile handle for palladium-catalyzed Suzuki couplings with various aryl/heteroaryl halides.
• Library Synthesis for Drug Discovery: Enables high-throughput parallel synthesis of diverse compound libraries for screening in medicinal chemistry programs.

Basic Information

Item	Details
Product Name	2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethyl)Benzaldehyde
CAS No.	1356948-22-5
Molecular Formula	C14H16BF3O3
Molecular Weight	300.09 g/mol
Synonyms	3-(Trifluoromethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde; 2-Formyl-6-(trifluoromethyl)phenylboronic acid pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)benzenecarboxaldehyde; (2-Formyl-6-(trifluoromethyl)phenyl)boronic acid pinacol ester; 3-Trifluoromethyl-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzaldehyde
EINECS	Contact for details

Quality Control

Our 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethyl)Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maximize shelf-life stability, as the compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.