Description

5-Fluoro-4-Picoline-3-Boronic Acid Pinacol Ester is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound is a critical intermediate in the synthesis of complex molecules, particularly in the development of pharmaceuticals and advanced materials. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for cross-coupling reactions.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing biaryl and heterobiaryl structures in drug discovery and development.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) and candidate molecules, especially those containing fluorinated pyridine motifs.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with enhanced properties.
• Material Science Research: Employed in the development of organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Chemical Biology & Proteomics: Useful as a probe or linker in the development of chemical tools and bioconjugates.
• Academic & Industrial R&D: A versatile reagent for methodological development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	5-Fluoro-4-Picoline-3-Boronic Acid Pinacol Ester
CAS No.	1356483-70-9
Molecular Formula	C₁₂H₁₇BFNO₂
Molecular Weight	237.08 g/mol
Synonyms	5-Fluoro-4-methylpyridine-3-boronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-fluoro-4-methylpyridine; 5-Fluoro-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-Fluoro-4-picoline-3-boronic acid, pinacol ester; 3-Borono-5-fluoro-4-picoline pinacol ester; 5-Fluoro-4-methyl-3-pyridinylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 5-Fluoro-4-Picoline-3-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. Each lot is analyzed using advanced spectroscopic and chromatographic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.