Description

2-((Tetrahydrofuran-3-Yl)Oxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole is a sophisticated heterocyclic building block that combines a thiazole core with a tetrahydrofuran ether and a pinacol boronate ester functional group. This compound is of significant value in modern synthetic chemistry, primarily serving as a key intermediate in cross-coupling reactions for the construction of complex molecules. It is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in drug discovery and the development of novel active ingredients. The specific molecular architecture makes it a versatile precursor for creating libraries of compounds with potential biological activity.

Application

• Pharmaceutical Intermediate: A critical building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides with optimized properties.
• Material Science: Serves as a monomer or functionalization agent in the synthesis of advanced polymers and organic electronic materials.
• Chemical Biology: Employed as a probe or linker in bioconjugation chemistry and the development of biochemical tools.
• Academic & Contract Research: A valuable reagent for methodology development and complex molecule synthesis in research laboratories.
• Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery campaigns.

Basic Information

Item	Detail
Product Name	2-((Tetrahydrofuran-3-Yl)Oxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole
CAS No.	1356469-05-0
Molecular Formula	C13H20BNO4S
Molecular Weight	297.18 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-((tetrahydrofuran-3-yl)oxy)thiazole; 2-(Tetrahydrofuran-3-yloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; Thiazole, 2-((tetrahydro-3-furanyl)oxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Boronic acid, B-[2-[(tetrahydro-3-furanyl)oxy]-4-thiazolyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 2-((Tetrahydrofuran-3-Yl)Oxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting customer specifications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We support development and regulatory needs with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (H-NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.