Description

3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-n-(2,2,2-Trifluoroethyl)Pyridin-2-Amine is a high-value, synthetically versatile organoboron building block, specifically a pyridine-substituted pinacol boronic ester. This compound is critical for modern cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing biaryl and heterobiaryl scaffolds found in drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific pyridine-based structures.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Proteomics: Employed in the synthesis of chemical probes and affinity tags for studying biological systems and protein interactions.
• Catalyst & Ligand Development: Utilized to synthesize novel nitrogen-containing ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds on a commercial scale.

Basic Information

Product Name	3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-n-(2,2,2-Trifluoroethyl)Pyridin-2-Amine
CAS No.	1356363-75-1
Molecular Formula	C14H20BF3N2O2
Molecular Weight	316.13 g/mol
Synonyms	2-Amino-3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2,2,2-trifluoroethyl)pyridine; 3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2,2,2-trifluoroethyl)pyridin-2-amine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methyl-N-(2,2,2-trifluoroethyl)pyridin-2-amine; 1356363-75-1; Boronic acid, B-[2-[[(2,2,2-trifluoroethyl)amino]-3-methyl-4-pyridinyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; Pinacol [2-[[(2,2,2-trifluoroethyl)amino]-3-methyl-4-pyridinyl]boronate
EINECS	Contact for details

Quality Control

Our 3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-n-(2,2,2-Trifluoroethyl)Pyridin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee batch-to-batch consistency and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.