Description

5-Chloro-2,3-dimethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a high-value, organoboron building block essential for modern synthetic chemistry, particularly in cross-coupling reactions. This compound is critical for the efficient construction of complex molecular architectures, enabling the development of novel active pharmaceutical ingredients (APIs) and advanced materials. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for lead optimization and process chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used to construct complex heterocyclic scaffolds found in advanced herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules and probes for studying biological pathways and protein interactions.
• Process Chemistry & Scale-up: Utilized in route development and optimization for the commercial-scale manufacturing of fine chemicals.
• Academic & Contract Research: A vital reagent for methodological development and library synthesis in academic and contract research organizations (CROs).

Basic Information

Product Name	5-Chloro-2,3-dimethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
CAS No.	1356165-74-6
Molecular Formula	C13H19BClNO4
Molecular Weight	299.56 g/mol
Synonyms	5-Chloro-2,3-dimethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(5-Chloro-2,3-dimethoxypyridin-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dimethoxypyridine; 1356165-74-6; 5-Chloro-2,3-dimethoxypyridine-4-boronic acid pinacol ester; 4-Pyridineboronic acid, 5-chloro-2,3-dimethoxy-, pinacol ester
EINECS	Contact for details

Quality Control

Our 5-Chloro-2,3-dimethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.