Description

1-(2,3-Difluoro-4-Methoxyphenyl)-2,2,2-Trifluoroethanone is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its unique structure, featuring both difluoromethoxy and trifluoroacetyl groups, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance bioavailability, metabolic stability, and binding affinity.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Organic Synthesis Reagent: Acts as a versatile trifluoroacetylation agent or a scaffold for constructing complex heterocycles in medicinal and process chemistry.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research exploring the effects of strategic fluorine substitution on molecular properties and reactivity.

Basic Information

Product Name	1-(2,3-Difluoro-4-Methoxyphenyl)-2,2,2-Trifluoroethanone
CAS No.	1356109-99-3
Molecular Formula	C9H5F5O2
Molecular Weight	240.13 g/mol
Synonyms	2,3-Difluoro-4-methoxy-α,α,α-trifluoroacetophenone; 2',3'-Difluoro-4'-methoxy-2,2,2-trifluoroacetophenone; 1-(2,3-Difluoro-4-methoxyphenyl)-2,2,2-trifluoroethan-1-one; 2,2,2-Trifluoro-1-(2,3-difluoro-4-methoxyphenyl)ethanone; α,α,α-Trifluoro-2,3-difluoro-4-methoxyacetophenone
EINECS	Contact for details

Quality Control

Our production of 1-(2,3-Difluoro-4-Methoxyphenyl)-2,2,2-Trifluoroethanone adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain optimal purity and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.