Description

tert-Butyl 3-(6-Fluoropyridin-2-Yl)Azetidine-1-Carboxylate is a high-value, protected azetidine building block designed for advanced pharmaceutical research and development. This compound is critical for medicinal chemists seeking to incorporate the azetidine ring system, a privileged scaffold known for improving the pharmacokinetic and pharmacodynamic profiles of drug candidates. It is primarily utilized in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, inflammation, and oncology. Our supply ensures the high purity and batch-to-batch consistency required for successful lead optimization and preclinical studies.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel small-molecule therapeutics.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead compound optimization, particularly for CNS targets.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker or component in the design of bifunctional degraders.
• Chemical Biology Probes: Employed in the synthesis of tool compounds for investigating biological pathways and target validation.
• Agrochemical Research: Potential intermediate in the discovery of new crop protection agents with novel modes of action.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for clients.

Basic Information

Product Name	tert-Butyl 3-(6-Fluoropyridin-2-Yl)Azetidine-1-Carboxylate
CAS No.	1356109-81-3
Molecular Formula	C13H17FN2O2
Molecular Weight	252.29 g/mol
Synonyms	1-Boc-3-(6-fluoro-2-pyridyl)azetidine; 1-(tert-Butoxycarbonyl)-3-(6-fluoropyridin-2-yl)azetidine; tert-Butyl 3-(6-fluoro-2-pyridinyl)-1-azetidinecarboxylate; 3-(6-Fluoropyridin-2-yl)azetidine-1-carboxylic acid tert-butyl ester; Azetidine-1-carboxylic acid, 3-(6-fluoro-2-pyridinyl)-, 1,1-dimethylethyl ester; 1356109-81-3; 1-N-Boc-3-(6-fluoro-2-pyridyl)azetidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(6-Fluoropyridin-2-Yl)Azetidine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and conformity to client specifications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent degradation. Allow the sealed container to equilibrate to room temperature before use to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.