Description

2-(3-Hydroxypiperidin-1-Yl)Pyrimidine-5-Boronic Acid Pinacol Ester is a sophisticated boronic ester derivative, a crucial building block in modern synthetic chemistry. Its value lies in enabling the efficient construction of complex molecules through reliable cross-coupling reactions, particularly the Suzuki-Miyaura reaction. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients. Its specific structure makes it a key reagent for creating novel compounds with potential therapeutic or biological activity.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry programs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aryl/heteroaryl groups, a fundamental reaction for constructing complex molecular architectures.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require specific heterocyclic frameworks.
• Chemical Biology & Probe Development: Serves as a versatile handle for creating molecular probes and tools to study biological systems and protein interactions.
• Material Science Precursor: Potential use in synthesizing organic electronic materials and ligands for catalysts due to its functionalized heterocyclic boronate structure.
• Contract Research & Development (CRO/CMO): Supplied to research organizations and custom synthesis facilities for client-directed projects requiring specialized boronic esters.

Basic Information

Product Name	2-(3-Hydroxypiperidin-1-Yl)Pyrimidine-5-Boronic Acid Pinacol Ester
CAS No.	1355388-42-9
Molecular Formula	C15H24BN3O3
Molecular Weight	305.18 g/mol
Synonyms	2-(3-Hydroxypiperidin-1-yl)pyrimidine-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(3-hydroxypiperidin-1-yl)pyrimidine; 2-(3-Hydroxy-1-piperidinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 1-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)piperidin-3-ol; CAS 1355388-42-9; Boronic acid, B-[2-[(3-hydroxy-1-piperidinyl)]-5-pyrimidinyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 2-(3-Hydroxypiperidin-1-Yl)Pyrimidine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity suitable for sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.