Description

1-(4-Formylphenyl)Azetidine-3-Carboxylic Acid is a high-purity, multifunctional organic building block featuring both an aldehyde and a carboxylic acid group on an azetidine scaffold. This compound matters as a critical intermediate for synthesizing novel pharmaceuticals and advanced materials, enabling the construction of complex molecular architectures. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for drug discovery programs and the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Peptidomimetic Research: Used to introduce constrained azetidine rings into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand Synthesis: Serves as a precursor for creating novel chelating agents and catalysts in asymmetric synthesis.
• Covalent Inhibitor Development: The reactive aldehyde group can be utilized for the design of targeted covalent inhibitors.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for synthesizing functional polymers with specific chemical handles.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes for studying enzyme function and mechanism.

Basic Information

Product Name	1-(4-Formylphenyl)Azetidine-3-Carboxylic Acid
CAS No.	1355248-05-3
Molecular Formula	C11H11NO3
Molecular Weight	205.21 g/mol
Synonyms	4-(3-Carboxyazetidin-1-yl)benzaldehyde; 1-(4-Formylphenyl)azetidine-3-carboxylic acid; Azetidine-3-carboxylic acid, 1-(4-formylphenyl)-; 4-(Azetidine-3-carboxylic acid)benzaldehyde; 1-(4-Carboxaldehyde phenyl)azetidine-3-carboxylic acid; 4-(3-Carboxy-1-azetidinyl)benzaldehyde
EINECS	Contact for details

Quality Control

Our 1-(4-Formylphenyl)Azetidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications in cGMP and ISO-certified environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.