Description

2-Cyclopropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethyl)Pyridine CAS NO 1355071-84-9 is a high-value, multi-functional boronic ester derivative, serving as a critical advanced pharmaceutical intermediate and building block in modern synthetic chemistry. Its molecular architecture, featuring both a cyclopropyl group and a protected boronic acid moiety, makes it indispensable for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and material science sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced biological activity and metabolic stability.
• Material Science Precursor: Employed in the creation of organic electronic materials, such as ligands for OLEDs and charge-transport materials, due to its conjugated pyridine core and functional handles.
• Cross-Coupling Reactions: A specialized reagent for palladium-catalyzed Suzuki-Miyaura couplings, enabling the efficient formation of carbon-carbon bonds to create biaryl and heterobiaryl structures.
• Chemical Research & Development: Serves as a versatile scaffold in academic and industrial R&D for exploring new chemical spaces and synthesizing complex molecular libraries.
• Ligand Synthesis: Used to prepare sophisticated ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2-Cyclopropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethyl)Pyridine
CAS No.	1355071-84-9
Molecular Formula	C15H19BF3NO2
Molecular Weight	313.13 g/mol
Synonyms	3-(Trifluoromethyl)-2-cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Cyclopropyl-3-trifluoromethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-cyclopropyl-3-(trifluoromethyl)pyridine; 2-Cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine; Pinacol 2-cyclopropyl-3-(trifluoromethyl)pyridine-5-boronate; 2-Cyclopropyl-3-trifluoromethylpyridine-5-boronic acid pinacol ester; CAS 1355071-84-9
EINECS	Contact for details

Quality Control

Every batch of our 2-Cyclopropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethyl)Pyridine is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.