Description

3-Chloro-2-Cyclopropyl-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl and heterobiaryl structures. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and material science industries to accelerate the discovery and development of novel active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex pyridine and cyclopropyl motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, ligands for catalysis, and functional polymers.
• Suzuki-Miyaura Cross-Coupling: The protected boronic ester group makes this compound an ideal, stable partner for palladium-catalyzed cross-coupling to introduce the pyridine moiety into more complex molecules.
• Contract Research & Development (CRO/CMO): Supplied to research organizations and custom synthesis facilities for client-directed projects and library synthesis.
• Academic Research: Employed in university and institutional labs for methodological development and the exploration of new chemical spaces.

Basic Information

Product Name	3-Chloro-2-Cyclopropyl-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1355067-20-7
Molecular Formula	C14H19BClNO2
Molecular Weight	279.57 g/mol
Synonyms	3-Chloro-2-cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Cyclopropyl-3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-chloro-2-cyclopropylpyridine; 3-Chloro-2-cyclopropylpyridine-5-boronic acid pinacol ester; Pinacol (3-chloro-2-cyclopropylpyridin-5-yl)boronate; CAS 1355067-20-7; Boronic ester intermediate 1355067-20-7
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-2-Cyclopropyl-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry. A detailed Certificate of Analysis (COA) specifying purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.