Description

2-Isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine is a high-value, organoboron building block essential for modern synthetic chemistry, particularly in cross-coupling reactions. Its core value lies in enabling the efficient and precise construction of complex pyrimidine-containing molecules, which are critical scaffolds in pharmaceutical and agrochemical discovery. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a key boronic ester reagent for constructing carbon-carbon bonds to introduce the pyrimidine moiety into target molecules.
• Pharmaceutical Intermediate: For the synthesis of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides containing pyrimidine rings.
• Material Science Research: As a precursor for creating organic electronic materials, such as ligands for OLEDs or molecular sensors.
• Chemical Biology Probes: For labeling and modifying biomolecules to study biological pathways and protein interactions.
• Library Synthesis: In medicinal chemistry for the parallel synthesis of diverse compound libraries for high-throughput screening.

Basic Information

Item	Detail
Product Name	2-Isopropoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine
CAS No.	1355066-82-8
Molecular Formula	C13H21BN2O3
Molecular Weight	264.13 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-isopropoxypyrimidine; 2-Isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-(Isopropoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-isopropoxypyrimidine; Pinacol 2-Isopropoxypyrimidine-5-boronate; 2-Isopropoxy-5-pyrimidineboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.