Description

4-(Trifluoromethyl)-Tetrahydro-2H-Pyran-4-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a trifluoromethylated tetrahydropyran scaffold. This compound is valued for its role in modulating the physicochemical properties of active molecules, enhancing metabolic stability and membrane permeability. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel therapeutic and crop protection agents. The hydrochloride salt form offers improved handling characteristics and solubility for downstream synthetic applications.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, infectious diseases, and oncology.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and insecticides, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Chemical Biology Probe Synthesis: Used to create tool compounds and molecular probes for studying biological pathways and target validation in academic and industrial research settings.
• Material Science Applications: Potential monomer or additive in the development of specialty polymers and advanced materials with unique surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	4-(Trifluoromethyl)-Tetrahydro-2H-Pyran-4-Amine Hydrochloride
CAS No.	1354961-50-4
Molecular Formula	C7H13ClF3NO
Molecular Weight	219.63 g/mol
Synonyms	4-Amino-4-(trifluoromethyl)tetrahydro-2H-pyran hydrochloride; 4-(Trifluoromethyl)-4-aminotetrahydropyran hydrochloride; 4-(Trifluoromethyl)tetrahydro-2H-pyran-4-amine HCl; Tetrahydro-2H-pyran-4-amine, 4-(trifluoromethyl)-, hydrochloride; 4-(Trifluoromethyl)tetrahydropyran-4-amine hydrochloride
EINECS	Contact for details

Quality Control

Our production of 4-(Trifluoromethyl)-Tetrahydro-2H-Pyran-4-Amine Hydrochloride adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure consistency and reliability. Certificates of Analysis (COA) documenting all critical quality attributes are provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates, and specifications can be aligned with customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after initial opening to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.