Description

2-Methyl-1-((4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Oxy)Propan-2-Amine is a high-value, advanced pharmaceutical intermediate featuring a pyridine core and a protected boronic ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily sought after by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) for oncology, CNS, and antiviral therapies.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific biaryl motifs.
• Material Science Research: Serves as a precursor for organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and enzyme inhibitors for target validation and drug discovery.
• Catalyst Ligand Synthesis: A starting material for creating sophisticated ligand systems used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and small-molecule libraries.

Basic Information

Item	Details
Product Name	2-Methyl-1-((4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Oxy)Propan-2-Amine
CAS No.	1354911-22-0
Molecular Formula	C16H27BN2O3
Molecular Weight	306.21 g/mol
Synonyms	2-Methyl-1-[(4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)oxy]propan-2-amine; 2-Amino-2-methylpropyl 4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl ether; 5-(Pinacolatoboryl)-4-methyl-2-((2-amino-2-methylpropoxy)pyridine; Boronic ester pyridine intermediate; Pinacol boronate pyridine derivative; Suzuki-Miyaura coupling reagent; BOC-protected aminopropoxy pyridine boronate
EINECS	Contact for details

Quality Control

Our 2-Methyl-1-((4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Oxy)Propan-2-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Production adheres to cGMP guidelines where applicable. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.