Description

1-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)-1,2,3,4-Tetrahydroquinoline is a high-value organoboron building block, specifically a pinacol boronate ester derivative of a tetrahydroquinoline-pyridine hybrid scaffold. This compound is critical for modern synthetic chemistry, enabling the formation of carbon-carbon bonds via cross-coupling reactions. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing biaryl and heterobiaryl structures found in drug candidates.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging its boronate functionality for molecular diversification.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or organic semiconductors.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules and probes for studying biological pathways and target engagement.
• Catalyst and Ligand Development: Utilized as a starting material for synthesizing novel catalysts and chiral ligands used in asymmetric synthesis.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	1-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)-1,2,3,4-Tetrahydroquinoline
CAS No.	1354911-19-5
Molecular Formula	C21H27BN2O2
Molecular Weight	350.27 g/mol
Synonyms	1-(4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)-1,2,3,4-tetrahydroquinoline; 2-(6-(1,2,3,4-Tetrahydroquinolin-1-yl)-5-methylpyridin-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1,2,3,4-Tetrahydro-1-[4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]quinoline; Quinoline, 1,2,3,4-tetrahydro-1-[4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-; CAS 1354911-19-5
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity (HPLC), identity (NMR, IR), and impurity profiles are available upon request. We adhere to cGMP principles where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.