Description

2-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Octahydro-1H-Pyrido[1,2-A]Pyrazine is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling key carbon-carbon bond-forming reactions, such as the Suzuki-Miyaura cross-coupling, which are fundamental to modern medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly for complex small molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those targeting the central nervous system (CNS) and oncology.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a crucial coupling partner for the introduction of the pyridine-pyrazine moiety into target molecular architectures.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and the exploration of new chemical space in drug discovery programs.
• Process Chemistry & Scale-Up: Used in the development and optimization of scalable synthetic routes for potential APIs.
• Library Synthesis: Facilitates the rapid generation of diverse compound libraries for high-throughput screening in early-stage drug discovery.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global pharmaceutical R&D pipelines.

Basic Information

Product Name	2-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Octahydro-1H-Pyrido[1,2-A]Pyrazine
CAS No.	1354911-18-4
Molecular Formula	C23H36BN3O2
Molecular Weight	397.36 g/mol
Synonyms	1,1-Dimethylethyl 4-(4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)octahydro-1H-pyrido[1,2-a]pyrazine-2(6H)-carboxylate (related Boc-protected precursor); 2-(4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)decahydropyrido[1,2-a]pyrazine; Pyrido[1,2-a]pyrazine boronic ester; Advanced pharmaceutical intermediate 1354911-18-4; Suzuki coupling partner; Pinacol boronate ester intermediate.
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Octahydro-1H-Pyrido[1,2-A]Pyrazine is manufactured and analyzed under strict quality management systems. Our products undergo rigorous testing to ensure compliance with the high-purity standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the certificate of analysis. Due to its hygroscopic nature, the container should be sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to maintain product integrity and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.