Description

1-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperidine-4-Carbonitrile is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl architectures. It is primarily utilized by pharmaceutical R&D and process chemistry teams engaged in the discovery and development of novel small-molecule therapeutics, particularly in oncology and CNS disease areas.

Application

• Key Building Block in API Synthesis: Serves as a crucial intermediate for constructing complex molecules in active pharmaceutical ingredient (API) development pipelines.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester moiety enables efficient palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides.
• Medicinal Chemistry & Drug Discovery: Used extensively in lead optimization and library synthesis to explore structure-activity relationships (SAR) around the piperidine-pyridine core.
• Prototyping Novel Kinase Inhibitors: The structural motif is common in the design of protein kinase inhibitors for cancer treatment.
• Process Research & Scale-Up: Supplied for route scouting and optimization studies from milligram to kilogram scale.
• Contract Manufacturing (CMO/CDMO): Sourced by contract organizations for cGMP manufacturing of clinical trial materials and commercial APIs.

Basic Information

Product Name	1-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperidine-4-Carbonitrile
CAS No.	1354911-08-2
Molecular Formula	C19H26BN3O2
Molecular Weight	339.24 g/mol
Synonyms	4-Cyano-1-[4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperidine; 1-[4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]piperidine-4-carbonitrile; 2-(4-Cyanopiperidin-1-yl)-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Piperidine-4-carbonitrile, 1-[4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-; 1354911-08-2; 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(4-cyanopiperidin-1-yl)pyridine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and LC-MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results. We support development under cGMP guidelines for applications requiring regulatory filing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.