Description

2-(4-Fluoro-Benzenesulfonylmethyl)-Pyrrolidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a distinct sulfonylmethyl pyrrolidine structure. This compound is valued for its role as a key building block in the synthesis of novel bioactive molecules, particularly in medicinal chemistry research and development. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating new therapeutic agents, especially within central nervous system (CNS) and enzyme inhibitor programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Protease Inhibitor Development: The sulfonylmethyl pyrrolidine moiety is relevant in the design of enzyme inhibitors, including potential protease inhibitors.
• CNS-Active Compound Synthesis: Employed in the research and development of novel compounds intended for neurological and psychiatric disorders.
• Chemical Biology Probes: Serves as a starting material for creating tool compounds used to study biological processes and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	2-(4-Fluoro-Benzenesulfonylmethyl)-Pyrrolidine Hydrochloride
CAS No.	1353977-86-2
Molecular Formula	C12H16FNO2S • HCl
Molecular Weight	293.79 g/mol (Free base: 257.32 g/mol)
Synonyms	2-[(4-Fluorophenyl)sulfonylmethyl]pyrrolidine hydrochloride; 1-(4-Fluorobenzenesulfonylmethyl)pyrrolidine hydrochloride; 4-Fluoro-N-(pyrrolidin-2-ylmethyl)benzenesulfonamide hydrochloride; Pyrrolidine, 2-[(4-fluorophenyl)sulfonylmethyl]-, hydrochloride; 2-(4-Fluorobenzenesulfonylmethyl)pyrrolidine HCl
EINECS	Contact for details

Quality Control

Our 2-(4-Fluoro-Benzenesulfonylmethyl)-Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing key parameters such as assay, impurity profile, and residual solvents. Our quality commitment supports both research-grade and cGMP-grade supply chains for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.