Description

1-Bromo-4-Cyclopropyl-2-Fluorobenzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound is valued for its unique molecular architecture, which combines a halogenated benzene core with a cyclopropyl substituent, enabling precise structural modifications. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine atom and cyclopropyl group enhance biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for the development of advanced organic electronic materials, such as semiconductors and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination, facilitating carbon-carbon and carbon-heteroatom bond formation.
• Chemical Biology Probes: Utilized in the creation of fluorinated probes and tags for studying biological mechanisms and drug-target interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated aromatic compounds.

Basic Information

Product Name	1-Bromo-4-Cyclopropyl-2-Fluorobenzene
CAS No.	1353854-74-6
Molecular Formula	C9H8BrF
Molecular Weight	215.06 g/mol
Synonyms	4-Bromo-1-cyclopropyl-2-fluorobenzene; 2-Fluoro-4-bromo-1-cyclopropylbenzene; 1-Cyclopropyl-4-bromo-2-fluorobenzene; Benzene, 1-bromo-4-cyclopropyl-2-fluoro-; (4-Bromo-2-fluorophenyl)cyclopropane
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Cyclopropyl-2-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure a typical purity of ≥97% (GC) and conformity to customer specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.