Description

2-(1-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperidin-4-Yl)Ethanol is a high-value, functionalized boronic ester derivative that serves as a critical advanced pharmaceutical intermediate (API). This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry. It is an essential building block for medicinal chemists and process R&D teams in the pharmaceutical and agrochemical industries, enabling the efficient construction of complex molecules for drug discovery and development.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between the boronic ester moiety and aryl/vinyl halides, crucial for constructing biaryl and heterobiaryl scaffolds.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop novel therapeutic compounds.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents and herbicides.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and ligands for catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke molecules under cGMP or research-grade conditions.

Basic Information

Product Name	2-(1-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperidin-4-Yl)Ethanol
CAS No.	1353742-98-9
Molecular Formula	C20H31BN2O3
Molecular Weight	358.29 g/mol
Synonyms	4-(2-Hydroxyethyl)-1-[4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperidine; 2-[1-[4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]-4-piperidyl]ethanol; 2-(Piperidin-4-ylethanol) Boronic Acid Pinacol Ester Derivative; 4-Methyl-5-(pinacolboron)-2-(4-(2-hydroxyethyl)piperidin-1-yl)pyridine
EINECS	Contact for details

Quality Control

Our 2-(1-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperidin-4-Yl)Ethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can be aligned with ICH guidelines to support regulatory filings for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon/nitrogen) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.