Description

(1-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperidin-4-Yl)Methanol is a sophisticated boronic ester derivative, a key intermediate in modern pharmaceutical and agrochemical research. Its core value lies in enabling Suzuki-Miyaura cross-coupling reactions, a pivotal method for constructing carbon-carbon bonds in complex molecules. This compound is essential for medicinal chemists and process development scientists working on small molecule drug candidates, particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, leveraging the boronic ester functionality for structural diversification.
• Material Science: Serves as a precursor for advanced organic electronic materials and functional polymers.
• Chemical Synthesis: Enables the efficient introduction of the substituted pyridinyl-piperidinyl-methanol moiety into complex molecular architectures via palladium-catalyzed cross-coupling.
• Process Chemistry: Employed in route scouting and scale-up for the commercial manufacturing of fine chemicals.
• Contract Research & Development (CRO/CDMO): A valuable reagent for custom synthesis and library production for client projects.

Basic Information

Product Name	(1-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperidin-4-Yl)Methanol
CAS No.	1353723-67-7
Molecular Formula	C19H31BN2O3
Molecular Weight	346.28 g/mol
Synonyms	4-Piperidinemethanol, 1-[4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-; 1-(4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperidin-4-ylmethanol; 2-(4-(Hydroxymethyl)piperidin-1-yl)-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; (1-(4-Methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperidin-4-yl)methanol; Pinacol [1-(4-methyl-5-pyridinyl)piperidin-4-yl]methanolboronate
EINECS	Contact for details

Quality Control

Our (1-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperidin-4-Yl)Methanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for advanced intermediates and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature: 2-8°C for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.