Description

4-Methyl-N,n-Dipropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group, which is critical for modern cross-coupling reactions. This compound is essential for enabling efficient and selective carbon-carbon bond formation, a cornerstone of complex molecule synthesis in drug discovery and development. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester reagent for constructing biaryl and heterobiaryl structures in medicinal chemistry.
• Pharmaceutical Intermediate: Used in the research and synthesis of potential drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Employed in the development of new active ingredients for crop protection products.
• Material Science Research: Acts as a building block for creating organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Provides a reliable and stable boronate source for optimizing and scaling synthetic routes from laboratory to pilot plant.

Basic Information

Product Name	4-Methyl-N,n-Dipropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine
CAS No.	1353723-55-3
Molecular Formula	C19H33BN2O2
Molecular Weight	332.29 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-N,N-dipropylpyridin-2-amine; 2-Amino-4-methyl-N,N-dipropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N,N-dipropylpyridin-2-amine; 1353723-55-3; Boronic acid, B-[2-[(dipropylamino)-4-methyl-5-pyridinyl]]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; Pinacol [4-methyl-5-(dipropylamino)pyridin-2-yl]boronate
EINECS	Contact for details

Quality Control

Our 4-Methyl-N,n-Dipropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to moisture. Recommended storage temperature is 2-8°C for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.