Description

n-Cyclohexyl-n-Ethyl-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is a high-value, organoboron building block designed for advanced synthetic chemistry. This compound matters because it provides a protected boronic ester functional group, enabling critical carbon-carbon bond-forming reactions like Suzuki-Miyaura cross-coupling with exceptional reliability. It is primarily needed by pharmaceutical R&D and fine chemical synthesis teams for constructing complex molecular architectures in drug discovery and material science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical coupling partner for introducing the pyridin-2-amine scaffold into biaryl or heterobiaryl systems under palladium catalysis.
• Medicinal Chemistry & Drug Discovery: Used in library synthesis for structure-activity relationship (SAR) studies and lead optimization campaigns.
• Ligand and Catalyst Development: Employed in the preparation of novel nitrogen-containing ligands for transition metal catalysts.
• Material Science Research: A building block for creating organic electronic materials and functional polymers with tailored properties.
• Agrochemical Synthesis: Intermediate in the development of new crop protection agents and herbicides.

Basic Information

Product Name	n-Cyclohexyl-n-Ethyl-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine
CAS No.	1353718-79-2
Molecular Formula	C₂₀H₃₃BN₂O₂
Molecular Weight	344.31 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-cyclohexyl-N-ethyl-4-methylpyridin-2-amine; 2-Pyridinamine, N-cyclohexyl-N-ethyl-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; N-Cyclohexyl-N-ethyl-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine; Pinacol [N-cyclohexyl(ethyl)amino-4-methylpyridin-5-yl]boronate; (N-Cyclohexyl-N-ethyl-4-methyl-5-pyridinyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our n-Cyclohexyl-n-Ethyl-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.