Description

Ethyl 2-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Ylamino)Acetate CAS NO 1353718-67-8 is a high-value, advanced pharmaceutical intermediate featuring a pyridine core and a protected boronic ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between the pyridine ring and various aryl/heteroaryl halides under palladium catalysis.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides requiring specific heterocyclic architectures.
• Material Science: Potential precursor for organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Serves as a versatile linker or warhead component in the design of bifunctional molecules for targeted protein degradation.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and library production for high-throughput screening.

Basic Information

Product Name	Ethyl 2-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Ylamino)Acetate
CAS No.	1353718-67-8
Molecular Formula	C18H29BN2O4
Molecular Weight	348.25 g/mol
Synonyms	Ethyl [2-[[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-2-pyridinyl]amino]acetate]; 2-[[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-2-pyridinyl]amino]acetic acid ethyl ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-pyridin-2-ylamino-acetic acid ethyl ester; 1353718-67-8; 2-Pyridineacetic acid, α-[[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-2-pyridinyl]amino]-, ethyl ester
EINECS	Contact for details

Quality Control

Our production of Ethyl 2-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Ylamino)Acetate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. All materials are characterized by advanced analytical techniques including HPLC, NMR (1H, 13C, 11B), and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The container should be kept tightly sealed in a dry inert atmosphere to protect the boronic ester moiety from potential hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.